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Adequate GSH maintains GPX4 in its reduced state, preventing oxidative inactivation, whereas GSH depletion leads to decreased GPX4 activity or even complete inactivation

Discontinuation rates in everyday settings are also higher than whats reported in clinical trials, highlighting the importance of a more tailored approach

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And in August, Pfizer ended development of its third and final oral GLP-1 candidate, PF-06954522, after a review of its phase 1 clinical performance and the overall GLP-1 landscape

As the field advances, integrating genetic and epigenetic profiling, including polygenic risk scores, transcriptomic signatures, and methylation markers, may enable more nuanced risk stratification and guide personalized treatment selection

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