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Alzheimers Dement 19:52965302

Alzheimers disease has historically been a difficult illness to treat and prevent given its complex nature and different presentations across patients

The other chains of cardiolipin remain in the membrane, thereby anchoring cytochrome c to the IMM

Additionally, PQ downregulates SLC7A11 and GPX4 expression and upregulates cyclooxygenase-2 expression, thereby promoting oxidative stress and ferroptotic cell death ( 4.2 Genetic models 4.2.1 SNCA models Overexpression of wild-type or mutant (A53T, A30P) -syn induces Lewy body-like inclusions in dopaminergic neurons, leading to significant neuron damage and degeneration

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