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In a prespecified pooled analysis, semaglutide was superior to placebo in improving heart failure-related symptoms and physical limitations, enhancing exercise tolerance, and promoting significant weight loss, underscoring its potential to address both metabolic and functional deficits in obesity-related HFpEF [49]

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2012;2(7):e134

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Concomitant antidiabetic therapies were frequently reported, with metformin being the most frequently reported concomitant medication (n = 1,879), followed by pioglitazone (n = 478), insulin glargine (n = 474), glipizide (n = 467), and glimepiride (n = 345) (Figure S1)

As much as possible, we focused on direct clinical research on tesamorelins effects on visceral fat, muscle development, and cognition