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Following this, there have been two clinical phase 2 trials (SAR425899 and MEDI0382 also known as cotadutide) published evaluating GLP-1/glucagon receptor co-agonists

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When to stop or modify protocols Discontinue or modify protocols if symptoms worsen progressively, if new neurological symptoms develop, if allergic reactions occur, or if significant side effects emerge

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It also gives laboratories a clearer way to separate this format from single-compound products that do not offer the same paired-pathway perspective