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Research highlights the crucial role of oxidative stress in the pathophysiology of PD [50, 66]

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This timing aligns with the peptide's potential effects on circadian rhythm regulation and natural melatonin production

Most gastrointestinal effects have been observed to diminish with continued exposure and gradual dose titration

Oral drugs undergo what is known as first-pass metabolism. First-pass metabolism is when the concentration of a drug, specifically when administered orally, is significantly reduced before it reaches systemic circulation