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M., Sandhurst, E

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While the study found no significant differences in the primary efficacy endpoint (time to first tolerated meal), the ipamorelin group showed reduced median time to first tolerated meal (25.3 hours versus 32.6 hours in placebo) and had fewer overall treatment-emergent adverse events (87.5% versus 94.8%)

Y.ChenH.et al (2023)

Mechanistically, mitochondria damage, manifesting as mitochondrial ROS increase, MMP depolarization and interference with mitochondrial respiratory chain, is a significant factor for autophagy and ferroptosis induction under nickel exposure (50)