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& Hu, S

Notably, ROS serve to stabilize HIF-1 under hypoxic conditions by inhibiting prolyl hydroxylases, further enhancing HIF-1 activity and establishing a positive feedback loop that sustains the hypoxia response

Riveline, D

Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices

POINTER study a two-year, multisite clinical trial that found intensive, structured lifestyle intervention (focused on physical exercise, nutrition, cardiovascular health monitoring, cognitive challenge, and social engagement) improved cognitive function in older adults at risk for decline

However, committee recommendations are advisory only and do not represent FDA drug approval