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In rat experiments, a decrease in phylloquinone (vitamin K 1 ) and menaquinone-4 (a form of vitamin K 2 ) concentrations in extra-hepatic tissues was found in animals administered excess -tocopherol via the diet or by subcutaneous injection

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150 Recently, it has been reported that human DNA ligase IV, a crucial enzyme in NHEJ, can acquire AMP moiety from NAD + for DNA end ligation

2 Diet can affect the gut microbiota Gut microbiota refers to the entire microbial ecosystem that inhabits the gastrointestinal tract of mammals, including bacteria, fungi, viruses, and protozoa (17)

14 In healthy people, the gut bacterium Clostridium bolteae converts primary bile acids into ursodeoxycholic acid, which is then conjugated into glycoursodeoxycholic acid (GUDCA)

New cells, such as neurons and red blood cells, require vitamin B12, as previously discussed