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Clinical trials often include pregnancy testing or contraception requirements, depending on the protocol

The lack of the placebo comparison at 2 years is also a limitation, but it did not seem feasible in terms of participant retention to maintain the placebo arm

Chawla LS, Chen S, Bellomo R, Tidmarsh GF (2018) Angiotensin converting enzyme defects in shock: implications for future therapy

Clinical trials have demonstrated that certain GLP-1 receptor agonists reduce the risk of major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease

Side effects are rare but can include mild discomfort at the injection site

For those with deficiencies, supplements may offer an effective solution