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Therefore, renal function needs to be assessed prior to initiating therapy and periodically thereafter (because changes in the recommendation occur rapidly with SGLT2 inhibitors please check the most recent package insert for the latest guidelines)

A third pathway also exists at intestinal sites subject to erosion and ulcerative damage permitting the passage of microbes and their products across the gut barrier as an outcome of its impaired integrity (Odenwald and Turner 2017

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