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In this episode of the Huberman Lab podcast, Dr

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You take certain medications: Long-term use of proton pump inhibitors (for acid reflux) or metformin (for diabetes) can interfere with B12 absorption

Furthermore, the overall bioavailability of L-5-MTHF is roughly 2.6 times higher, meaning a much larger percentage of the ingested dose actually makes it into the systemic circulation to be used by the cells

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