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The brain pathway may be more significant than the endocrine route for the physiological effects of GLP-1, especially regarding insulin release, but the endocrine route becomes more pronounced with bigger meals and more L-cell activation (Deacon 2019)

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Moreover, while there is substantial evidence supporting the cardioprotective role of GLP-1RA, the data is less conclusive for GIP and GCG, necessitating additional research to clarify their contributions to cardiovascular health

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