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Peroxiredoxin 2 and peroxide metabolism in the erythrocyte

In this study, the correlation between the CLOCK gene and the BMAL1 gene was not high, which was consistent with the view that different parts of the circadian clock system linked to different functions as circadian oscillators ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes

10.1016/j.jacep.2019.11.008 324

On the contrary, excessive ROS levels cause cell injury by damaging proteins, lipids, and nucleic acids, leading to different conditions, such as neurological diseases, hypertension, diabetes, atherosclerosis, heart failure, chronic kidney disease, and cancerogenesis [2]

6 PMC (2022)Reduced-calorie diet with NNMT inhibition establishes a distinct microbiome in DIO mice

This bypasses first-pass metabolism in the liver and avoids the stomach entirely