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However, that is no longer the case

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The most widely used anti-angiogenic agents include monoclonal antibodies and tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF) pathway

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Based on the in vivo experiment in the ICV-STZ rat model of AD, modulation of the PI3K/Akt/GSK3 signaling pathway could diminish oxidative stress, neuro-inflammation, and apoptosis, Moreover, amyloid plaque number and phosphorylated tau expression were marked decrement (Nishizaki, 2018)