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Melanotan I (Afamelanotide) is more selective for MC1R , primarily used for skin pigmentation in conditions like erythropoietic protoporphyria, and has higher stability than Melanotan II

Research shows that 73% of people who experience severe GI side effects discontinue treatment prematurely

one or more of AA is a hydrophilic amino acid

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They are not reviewed or approved by the FDA for safety or effectiveness and may be prescribed when FDA-approved alternatives are unavailable or unsuitable