(Clin Transl Med, 2021) in 24 older adults (aged 61-80) found that supplementation with GlyNAC (glycine 100 mg/kg/day + NAC 100 mg/kg/day, approximately 7 g each for a 70 kg person) for 16 weeks corrected glutathione deficiency and improved multiple hallmarks of aging including oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body composition, exercise capacity, and cognition [10]
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Whole cell GSH abundance (bottom left) and fold change in cell number (log 2 ) of HEK-293T cells expressing a vector control or engineered GshF cDNA treated with indicated BSO concentrations for 5 days (bottom right)
J Surg Oncol 121(6):984-989, 2020
This process can vary depending on several factors, including the form of glutathione being used (e.g., oral, liposomal, or intravenous)
Most recently, a randomized, double-blind, placebo-controlled trial in 81 children (8-14 years) residing in the UK found that use of a daily multivitamin/mineral supplement, containing most vitamins as well as iron, copper, zinc, calcium, and magnesium, was associated with an increase in accuracy on one attention task (Arrows Flankers test) throughout the 12-week study (106)
