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Moreover, the transcriptional induction of ERBB3 would result in intrinsic resistance to MEK inhibition, and targeting EGFR and ERBB2 (which can form a heterodimer with ERBB3) could overcome this resistance [58]

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Taking magnesium immediately before meals may interfere with stomach acid production needed for proper digestion, while taking it too late in the evening might cause sleep disruption in sensitive individuals