Skeletal muscle, although active at de novo fatty acid synthesis, have the lowest levels of expression of enzymes of the PPP
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Figure 1 Iron metabolism At present, the exact molecular mechanism of iron overload leading to heart damage is mainly considered to be ferroptosis (3336)
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It can therefore be concluded that ToxCast PPAR and RXR assays and some of the computational tool predictions available from the US EPA Chemical Dashboard, are suitable for high throughput screening (HTS) in the identification of potential hazards and prioritisation of chemicals from large chemical libraries that could not otherwise be screened in lower-throughput model systems
