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IGF-1 also plays a key role in maintaining epidermal homeostasis, helping to prevent skin aging and maintain a youthful appearance (Tavakkol et al., 1999)

The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot

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