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Niacinamide (vitamin B3) Niacinamide is sometimes added for its potential synergistic effects on metabolic health

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Compound 3 , ( E )2(3,4dihydroxy5nitrobenzylidene) N phenylhydrazine1carbothioamide, was potent in the order of nM, with an IC 50 value of 0.0437 M, being 734 times more potent than its analog 3,4dihydroxy5nitrobenzaldehyde (DHNB) and 173 times more potent than the drug allopurinol, demonstrating its excellent inhibitory activity (Figure 4)

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Pedre B, Barayeu U, Ezeria D, Dick TP