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J Gastroenterol Hepatol 2024;39:1939-1949

SGLT2is reduced the risk of major adverse cardiovascular events (MACE) in participants both receiving and not receiving GLP1-RAs, HR 0.81 (95% CI 0.631.03) vs HR 0.90 (95% CI 0.860.94

Both weight loss peptides and tirzepatide are GLP-1 agonistschemicals that bind to other cells and trigger a reactionhowever, tirzepatide imitates an additional hormone called GIP (glucose-dependent insulinotropic polypeptide)

Key distinctions include: Origin : GLP-1 is naturally occurring

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