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They notably regulate zinc and copper homeostasis, shield against oxidative stress, and detoxify heavy metals

E., Hwang, E

These compounds, designed using a bioisosteric approach, replaced the carboxylic acid function of indomethacin with hydroxylated azoles

CRediT authorship contribution statement Reshi Mohd Salim: Validation, Supervision, Resources, Methodology, Investigation, Formal analysis, Conceptualization

Targeting intermediary metabolism Farnesoid X receptor (FXR) agonists The nuclear FXR agonists may treat MASLD through various mechanisms, including alleviating insulin resistance and exerting direct anti-inflammatory and antifibrotic effects on MASH in both mouse models and human tissues

| doi:10.3945/ajcn.111.012047 Tang WHW, Li DY, Hazen SL.: Dietary metabolism, the gut microbiome, and heart failure