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These findings underscore the potential for developing additional therapeutic targets beyond MAOB inhibition

Sharma et al., 2024a)

Our findings align with previous findings, indicating that the induction of PCOS through letrozole administration resulted in elevated levels of LH and testosterone while simultaneously decreasing FSH levels compared with controls

The therapeutic effects arise through three primary mechanisms: central appetite suppression via hypothalamic GLP-1R activation (reducing food intake by 20-35%), delayed gastric emptying through vagal pathways (enhancing satiety per meal), and glucose-dependent insulin secretion from pancreatic beta cells (improving glycemic control)

If your plan covers one and not the other, that shapes the conversation with your provider significantly

High levels of ammonia in the blood can occur