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As the well-known glutamate-glutamine cycle, astrocytes play key roles in resolving neuronal glutamate toxicity

Biochem J 360:116

Initial tests on rodents highlighted its remarkable ability to decrease body weight, decrease food consumption, and offer improved blood sugar regulation over other agents like GLP-1 RA

And there it was: Zoloft can increase serotonin levels and thereby exacerbate RLS

Future research designs should go beyond simple body composition assessments, taking muscle strength, physical performance, and quality of life as core clinical endpoints to clarify the long-term effects of GLP-1RAs on different subgroups

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Amthor H, et al