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In a typical cancer setting, they act as a double-edged sword favoring the tumor by adopting a supporter (M2) phenotype

This profile was confirmed in the ensuing study where Atlas987 at orally active doses (as found in the experiments on antagonism of ()-8-OH-DPAT-induced serotonergic behavior) had no acute inhibitory effects on male rat sexual behavior

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Devlin 2 , Eric Sheu 1 1 Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States, 2 Harvard Medical School, Boston, Massachusetts, United States, 3 Affinivax, Cambridge, Massachusetts, United States 1

Several studies have reported that certain NPs can accumulate in brain tissue over extended periods, increasing the risk of toxicity and interference with normal cellular functions [177]