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Complement component C3 production and activation of complement and coagulation cascades, as highlighted by single-gene Gene Set Enrichment Analysis of immune-related biomarkers (CXCL12, PDGFRL, AGTR1, PTGER3, S1PR1), further support the involvement of inflammatory pathways in disease pathogenesis (69)
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There are six high-affinity binding proteins (insulin-like growth factor-binding protein [IGFBP]-1 to IGFBP-6) that are unrelated to the cell surface receptors [11]
