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Indian dermatology online journal , 8 (2), 104110

Tirzepatide's Phase 3 trials began in 2019

Patients with renal disease who undergo hemodialysis are at risk for secondary carnitine deficiency because hemodialysis removes carnitine from the blood (see End-stage renal disease) (38)

However, they may be more likely to discontinue their ICI due to an irAE, or be at higher risk of an irAE specific to their condition (for example, colitis in a patient with a history of IBD)

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The alteration has the potential to impact prices, besides how easy it is to obtain treatment for people who require tirzepatide to address diabetes and weight concerns