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Because many of these patients were GLP-1-naive, the rates in switchers from semaglutide are not precisely quantified in current literature

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For example, deferiprone (DFP) and PBT2 have been shown to increase endothelial tight junction protein expression in AD models, reduce vascular leakage, and improve BBB integrity, suggesting an indirect BBB-protective potential (Ayton et al., 2025)