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However, excessive masturbation can contribute to the development of this condition indirectly: _Friction and irritation_: Frequent masturbation can cause friction, leading to irritation and micro-tears in the skin

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Human eNOS+ enteric neurons in the submucosa also express the GLP-2R, supporting a direct role for GLP-2-mediated increase in eNOS protein and NOS release through cAMP-dependent protein kinase A (Guan et al., 2006) (Table 3)