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chronic), and a persons individual susceptibility

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GLP-1R activates the PI3K/Foxo1 pathway to promote -cell survival, and can also recruit -arrestins, which regulate receptor trafficking and desensitization, and can also modulate downstream extracellular signal-regulated kinases (ERK1/2), thereby influencing -cell function in a context-dependent manner (28,29)

doi: 10.1016/0003-2697(87)90085-6

Certain thyroid conditions carry additional considerations: people with a history of medullary thyroid cancer or MEN syndrome cannot use GLP-1 medications due to FDA warnings