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(2024) 12:e17891

N Engl J Med 2021;384:1113-1124

Unlike conventional GLP-1 agonists that primarily target a single receptor pathway, GEP-44 functions as a triple agonist targeting GLP-1 and peptide YY receptors Y1 and Y2

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They found that the enzyme responsible for ADP-heptose production, HldE (Amuc_0415), is present in the genome of A