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First-pass metabolism occurs when a compound is absorbed from the gut and passes through the liver, where it can be partially broken down before reaching the rest of the body

In the pathological process, inflammatory cytokines can directly or indirectly damage skin tissues and cells, leading to congestion and exudative responses (Shirley et al., 2024)

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Always consult your primary care provider or a licensed healthcare professional before making decisions about your health, including any treatment options or medication use

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