With the previously mentioned B12 absorption challenges, it is not advisable to use forms that are either unstable (adeno-B12) or forms (cyano) that take more energy to convert into the active methyl-B12
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The working model holds that high NNMT activity in fat tissue consumes nicotinamide and methyl donors in a way that favors fat storage over energy burn
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Polycythemia Vera: Use with caution as vitamin B12 may increase red blood cell production