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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

Furthermore, characteristic C-N and C-O stretching vibrations at 1238 cm and 1080 cm were retained in the DNZ-NLPs spectrum, reinforcing the successful encapsulation

10.1038/s41598-017-16663-0 46 DouglassA

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Another receptor with increased levels in progressive cancerous breast cells is estrogen receptor (ER), which can be targeted for peptide-based cancer therapy