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D-gal can cause the accumulation of ROS in vivo , ultimately result in oxidative stress 37

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Overexpression of GSTP1 has been reported to involve cancer cell resistance to chemotherapeutics, such as resistance of ovarian cancer cells against carboplatin and cisplatin, adriamycin-resistance of breast cancer cells and prostate cancer cells, resistance of gastric cancer cells against fluorouracil (5-FU) and cisplatin, and resistance of neurogliomas against cisplatin and irinotecan [99,100,101,102,103]

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