Unithroid and Levoxyl received an FDA approval via the new NDA requirements in August 2000 and May 2001, respectively
In addition to dose, other factors that affect the quantity of live bacteria that enter the intestine include formulation, gastric pH, intestinal motility, co-administration with food or milk (which protects against gastric acid), and the makeup of an individuals gut microbiota
Calculation is by measuring the amount of drug in the body over time and determining the time it takes for the drug concentration to be reduced by half
Especially in todays world where we are inundated with environmental toxins that mimic our natural estrogen, and our diets dont exactly encourage healthy estrogen detoxification
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Toxicol Appl Pharmacol 243:340347 Rajaei S, Alihemmati A, Abedelahi A (2019) Genistein antioxidant effect in PCOS