Scientists have learned over time that the potential health benefits of GLP-1s may extend beyond weight loss alone, however
Biotransformation Antiarrhythmic drugs (AADs) undergo metabolism in the liver through CYP450 isoenzymes, resulting in active metabolites that either block sodium (Na+) channels (such as mexiletine and propafenone), extend action potential duration (APD) [for instance, N-acetylprocainamide (NAPA)], or cause central nervous system (CNS) toxicity (as seen with lidocaine) (11)
Many researchers also feel that obesity is a chronic condition and that long-term treatment is recommended
Endocrine (2016) 51(2):32332.10.1007/s12020-015-0667-x 29 LuNSunHYuJWangXLiuDZhaoLet alGlucagon-like peptide-1 receptor agonist liraglutide has anabolic bone effects in ovariectomized rats without diabetes
Whilst some individuals may notice modest weight changes in the first month, the most substantial weight reduction in trials occurred progressively over 24 to 48 weeks , with continued benefit observed throughout the treatment period
Bombay: BBPH