Researchers are studying antioxidants like HPN-07 and NAC, but they have found that inhibiting a protein called PARP1 can reduce inflammation and protect the blood-brain barrier
The concentrations in other tissues were lower than the average concentration in the plasma and are presented in the descending order as follows: intestinal tract, lung, gonad, skin, skeletal muscle, cardiac muscle, whole blood, brain, and body fat
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Institute of Medicine
D.FerreiraG
The three compounds, in a rigorous research approach, require: strict analytical control (MS + HPLC 98%), adapted administration route (intranasal for BBB crossing), standardised behavioural model with positive control, and exhaustive documentation for publication