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Using a CRISPR KO screen targeting 64 KGDDs, we identified and validated TMLHE as the aKGDD driving these effects

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Symptoms overlap across diagnoses

Author contributions All authors above made substantial contributions to the conception or design of the work or the acquisition, analysis or interpretation of data for the work and drafting the work or revising it critically for important intellectual content and gave final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

* The unique structural changes allow EPA and DHA to bypass this blockade

References Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, et al