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Different manipulations affecting glutamate homeostasis were reported to induce compromised performance in hippocampus-dependent spatial acquisition tasks [51, 52] and mPFC-dependent reversal assays [53,54,55]
Finally, these observations provide a unique example of an intervention which appears to favor female healthspan and lifespan, thereby reinforcing the need for considering sex differences in devising therapeutic strategies to treat aging and its diseases
Toxicol Appl Pharmacol (2025) 498:117308
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In addition, IRE1 kinase can up-regulated the expression of apoptosis signal regulated kinase 1(ASK1) and then activate c-Jun N-terminal kinase (JNK) to promote apoptosis through the inhibition of BCL-2 protein family (64, 65)
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