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The degree of inflammation of the colon was graded semiquantitatively from 0 to 11 according to described criteria (Appleyard and Wallace, 1995) taking into consideration (1) loss of mucosal architecture (score 03), (2) cellular infiltration (score 03) (3) muscle thickening (score 03), (4) crypt abscess formation (score 01) and (5) goblet cell depletion (score 01)

doi: 10.1038/s41467-017-02375-6 21 LiWNWuMHTsaiSJ

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By incorporating such programs, they may reduce the long-term costs associated with chronic conditions like diabetes and cardiovascular diseases, improve patient adherence and satisfaction, and ultimately enhance overall population health