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Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gutmetabolismreproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (73)

Similarly, in hypothyroidism, before carnitine the correlation showed a non-significant trend ( rho = -0.24 Sig

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Towards better sinomenine-type drugs to treat rheumatoid arthritis: molecular mechanisms and structural modification