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Nat Commun 17 , 181 (2026)

The obtained active site model was further substantiated as amino acid residues Arg 166 , Arg 284 and Ser 447 were located at an appropriate distance for hydrogen bonding interaction with the carboxylate group of the substrate

Jin ES, Malloy CR, Sharma G, Finn E, Fuller KN, Reyes YG, et al

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Posteriormente se normalizaron y no presentaron variaciones significativas a lo largo del estudio en ninguna de las series (tabla 1)