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In this clinical trial, a total of 966 primary participants were randomly distributed into three groups in a 1:1:1 ratio, with 322 individuals in the 80 mg Resmetirom group, 323 in the 100 mg Resmetirom group, and 321 in the placebo group

A summary of endocrine influences on the hypothalamicpituitarygonadal axis is shown in Figure 1

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