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In spacing out the doses, it is hard to know the effective levels in your body and if they are consistent over time

Notably, Tora Lindqvist et al

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doi: 10.3389/fimmu.2020.596103 55 BousoikEQadriMElsaidKA

Non-diabetics in obesity trials often have more visceral fat that is more metabolically active and easier to mobilize while diabetics tend to have more ectopic fat thats harder to lose