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In the REDEFINE 1 phase 3 trial, cagrilintide 2.4 mg monotherapy produced an average body weight reduction of 11.8% over 68 weeks

10.1152/ajprenal.00089.2023 159 PadhiP.LouJ.JinH.AnantharamV.KanthasamyA.KanthasamyA

It is noteworthy that semaglutide also improved HCC burden in GAN DIO-NASH-HCC mice, suggesting additional benefits of GLP1R agonists in the management of NASH complicated by HCC

In pre-clinical studies, GLP-1 mediated delivery of estrogen or dexamethasone has proven beneficial effects on glucose tolerance, bodyweight control and systemic inflammation (81)

Common dose-limiting side effects include severe nausea, constipation, dehydration, and loss of appetite that becomes problematic rather than therapeutic

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