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The sulfhydryl group (-SH) on glutathione's cysteine residue binds directly to heavy metals including mercury, lead, cadmium, and arsenic, forming glutathione-metal conjugates that can be excreted through bile and ultimately eliminated from the body
These results might be related to the downregulation of MAPK signalling and the decreased inflammatory responses (180)
The growing incidence of diabetes among Indians, as in the world, is a relatively recent phenomenon and is probably the result of lifestyle changes associated with over-nutrition
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Once the state of activated ROS production reaches cells and tissues, other than those initiating the signal, it triggers acclimation mechanisms and enhances overall stress resilience (Fichman and Mittler, 2021a, b)