Natural peptide production begins declining in most people by their early thirties
PMID: 50 VazquezDSSchilbertHMDoderoVI
Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data
Phenothiazine normalizes the NADH/NAD(+) ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinsons disease
But, what about dose
161,186 Over the long term, B 12 deficiency can lead to a wide range of neurological disorders, including neuropathies, neuromuscular changes, cognitive impairment, depression, and neurodegenerative diseases