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Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

The detection of infectious agents not acceptable in UW rodent SPF housing was performed in concert with similar standards at Charles River and the NIA aging rodent colony