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it contains only semaglutide as its active ingredient with pharmaceutical excipients

3.2.3 Anti-inflammatory and anti-fibrotic effects Activation of GLP-1 receptors by dual agonists exerts potent anti-inflammatory effects within the liver microenvironment, which are crucial for preventing progression from steatosis to steatohepatitis and fibrosis

The recommended approach is to discontinue semaglutide, allow a washout period of at least 2-3 weeks (given semaglutide approximately one-week half-life), and then begin retatrutide titration from the standard 1 mg starting dose

American College of Cardiology